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Curcumin

Alzheimer's disease (AD) is diagnosed (by autopsy) by the presences of what are called neurofibrillary tangles, senile plaques and loss of neurons. It is clear that oxidative stress and inflammation have an important role in AD. Curcumin is a compound with broad spectrum antioxidant, anti-inflamatory and anti-fibrilogenic activities. One recent study suggests that the natural product curcumin represents a "hopeful approach for delaying or preventing the progression of AD". Other studies have shown that curcumin prevents neural damage and reduces both oxidative stress and plaque accumulation. Curcumin prevents the formation of new deposits, clearing existing deposits, and reducing the size of remaining deposits. This data confirms that not only can curcumin suppress new plaques but also remove previous deposited ones. Data also shows that well known supplements, such as vitamin E and Ginkgo Biloba extract, have no effect on these plaques. Curcumin represents the "new frontier" of health supplements in disease prevention and treatment.

These statements have not been evaluated by the U.S. Food and Drug Administration. These products are not intended to diagnose, cure or prevent any disease.

References

•  Garcia-Alloza M, Borrelli LA, Rozkalne A. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J Neurochem 2007; 102(4): 1095–1104.
•  Ono K, Naiki H, Yamada M. The development of preventives and therapeutics for Alzheimer's disease that inhibit the formation of beta-amyloid fibrils (fAbeta), as well as destabilize preformed fAbeta. Curr Pharm Des 2006; 12(33): 4357–4375.
•  Yang F, Lim GP, Begum AN, et al. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vitro. J. Biol. Chem. 280:5892-5901.

•  Cole GM, Morihara T, Lim GP, et al. NSAID and antioxidant prevention of Alzheimer's disease: lessons from in vitro and animal models. Ann N.Y. Acad. Sci. 1035, 68-84.
•  Kim DS, Kim JY, Han YS. Alzheimer's disease drug discovery from herbs: Neuroprotectivity from beta-amyloid (1-42) insult. J Altern Complement Med 2007; 13(3): 333–340.
•  Mancuso C, Bates TE, Butterfield DA, et al. Natural antioxidants in Alzheimer's disease. Expert Opin Investig Drugs 2007; 16(12): 1921-1931.

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