THE SCIENCE

Stabilized Rice Bran

Tapping into the Nutrition

Rice is the most consumed food on earth. 65% of the nutrition of the rice kernel is locked away in the rice bran which is the outer layer of the kernel. Rice bran is considered to be one of the most nutrient-dense naturally occurring foods available but it is routinely thrown away as an unused food resource. This is because rice bran contains an enzyme that causes rancidity within hours of milling, making it unfit for human consumption. In fact, more than 60 million metric tons of rice bran each year ends up as animal feed or dumped in landfills. In other words, the nutrient-dense part of the rice kernel never makes its way to our dinner table.

Not any more, thanks to a breakthrough in advanced extrusion technology. This gives stabilized rice bran a shelf life of up to three years and transforms it into a highly nutritious food for humans. How nutritious? According to a report published by the Alternative Medicine magazine, stabilized rice bran seems to be one of the most potent and accessible sources of a complex mix of phytonutrients and antioxidants. The report states: Nutraceuticals derived from stabilized rice bran are showing enormous nutritional value. So far, the most promising uses are against diabetes, high cholesterol, liver abnormalities and cardiovascular disease.¹

Health Benefits

These health benefits are not just anecdotal references. They are not based on occasional individual testimonies; instead, there have already been a number of clinical trials on rice bran, including the treatment of Type 1 and 2 diabetes^{1, 2}, high LDL cholesterol^{3, 4}, triglycerides⁴ and treatments for joint pain as well as joint inflammation.⁵ The results are astonishing! The initial clinical trials demonstrated that these products help reduce Type 1 and 2 diabetics' sugar levels by up to 30% and 20%, respectively.² Other clinical trials in the University of New Mexico Medical School indicated that 83% of test subjects demonstrated an improvement in the blood serum markers that affect their ability to dissolve blood clots - a major cardiovascular health risk for many people.

Rice bran is a treasure trove of phytonutrients, working both synergistically and in parallel. These phytonutrients are hard to come by in a typical diet, even for the health purist. They are believed to be useful in the nutritional management of certain metabolic disorders such as diabetes, hypertension and cardiovascular diseases. Tocotrienols, polyphenols, inositol hexaphosphate (IP6), non-starchy polysaccharides, gamma oryzanol and phytosterols are the major phytonutrients in Nussentials' stabilized rice bran products.

Rice bran and its products are one of the highest natural sources of phytosterols in nature. Phytosterols help reduce cholesterol by decreasing lipid (fats) circulating in the bloodstream. They are strong anti-inflammatory agents and immune-function enhancers, and decrease susceptibility to infection. They also help prevent cancer through their action of inhibiting abnormal cell growth. The following benefits of phytosterols have been demonstrated by scientific citations:

• Reducing total cholesterol ⁶
• Inhibiting the synthesis of LDL-C ⁷
• Reducing BPH (benign prostatic hyperplacia) ⁸
• Providing anti-inflammatory effect ⁹
• Inhibiting the growth of breast cancer cells¹⁰
• Inhibiting colon cancer cells¹¹
• Helping in Cancer prevention¹²
• Improving the immune system¹³

Rice bran products are also a good source of tocotrienols. The following benefits of tocotrienols have been demonstrated by scientific citations:

• Reducing total and LDL cholesterol¹⁴
• Reducing overall cancer risk¹⁵

These studies suggest that rice bran products have tremendous health benefits with tocotrienols and high phytosterols alone. Besides tocotrienols and phytosterols, several unique phytonutrients and antioxidants naturally present in rice bran contributing to health benefits, make it a super health food.

In fact, Nussentials' stabilized rice bran products include more than 100 different natural antioxidants. They are essential to maintain health in order to fight diseases. Natural antioxidants seldom work by themselves, but are very effective as part of an antioxidant system in which there is synergistic action. Our products contain a rich cocktail of unique antioxidants that work individually through different mechanisms and elicit a significant effect in the biological system.

What's it all Mean?

So what does all this mean? Why do Nussentials' stabilized rice bran based products work? They work because they nourish your body by providing an incredibly potent mix of naturally occurring vitamins, minerals, antioxidants and phytonutrients. We believe many of our health problems are a result of the most toxic and industrially processed food on earth. If you eat food deficient in minerals, your body becomes nutritionally deficient as well. You will not be able to build and maintain a healthy body because you are missing essential building blocks. As a result, you become vulnerable to various diseases.

Nussentials' stabilized rice bran products help you correct undernourishment and vitamin deficiency while providing your body with a mix of disease-fighting ingredients, such as phytosterols. The unique feature is that you can get so many vitamins, minerals, fiber, antioxidants and phytonutrients just by simply introducing this whole food - Nussentials' stabilized rice bran products into your daily diet!

These statements have not been evaluated by the U.S. Food and Drug Administration. These products are not intended to diagnose, cure or prevent any disease.

References
1.  Kamen, B. 2001. Stabilized Rice Bran. Alternative Medicine, 2001 Jul:53-66. 2.  Qureshi AA, Sami SA, Khan FA. Effects of stabilized rice bran, its soluble and fiber fractions on blood glucose levels and serum lipid parameters in humans with diabetes mellitus Types I and II. J Nutr Biochem 2002 Mar;13(3):175-187. 3.  Xu Z, Hua N, Godber JS. Antioxidant activity of tocopherols, tocotrienols, and gamma-oryzanol components from rice bran against cholesterol oxidation accelerated by 2,2í-azobis(2-methylpropionamidine) dihydrochloride. J Agric Food Chem 2001 Apr;49(4):2077-81. 4.  Qureshi AA, Sami SA, Salser WA, Khan FA. Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans. Atherosclerosis 2002 Mar;161(1):199-207. 5.  Ref: Cheruvanky et al., "Methods for Treating Joint Inflammation, Pain and Loss of Mobility," U.S. Patent No. 6,902,739, Nov 2001. 6.  Ostlund, Jr. R. E. 2003. Phytosterols in Human Nutrition. Annual Rev. in Nutrition, 22:533-49. 7.  Jones, P J H., Howell T., Natanios FY., Raeini-Sarjaz M, Vanstone CA., 1999. Cholesterol lowering efficacy of a sitostanol containing sitosterol mixture with prudent diet in hyperlipidemic men. Am.J. Clin. Nutr. 69:1144-50. 8.  Berges, K A.,Senge, T. 2000. Effect of Beta-sitosterol on transforming growth factor-beta-1 expression and translocation protein kinase C alpha in human prostate stomal cells in vitro. Eur. Urol., 37(6): 735-41.		9.  Gupta, M B., Nath, R., Srivatsava, N., Shankar, K., Kishor, K and Bhargava, K P. 1980. Anti-inflammatory and anti-Pyretic effect of beta-sitosterol. J. Medicinal plant Res. 39:157-163. 10.  Awad, A B., Downie, D., Fink, C S. 2000. Inhibition of growth and stimulation of apoptosis by beta-sitosterol treatment of human breast cancer MDA-MB-231 cells in culture. Int. J. Mol. Med,5:541-545. 11.  Awad, A B., von Holtz, R L., Cone, J P., Fink, C. S., Chen, Y-C. 1998. Beta-sitosterol inhibits the growth of HT-29 human coloncancer cells by activating shingomyelin cycle. m Anticancer Res. 18:471-479. 12.  Awad, A B. and Fink, C. S. 2000. Phytosterol as anticancer dietary component: Evidence and Mechanism of action. J.of Nutrition 130:2127-2130. 13.  Bouic, P J D., Estebeth, S., Leibenberg, R. W., Albrecht, C. F., Pegel, K., Van Jaarsveld, P P. 1996. Beta-sitosterol and beta-sitosterol glucoside stimulate human peripheral lymphocyte proliferation: Implication for their use as an immunomodulatory vitamin combination. Int. J. Immunopharmacology 18: 693-700 (Medline). 14.  Minhajuddina, M, Begb, Z, Iqbal, J. 2005. Hypolipidemic and antioxidant properties of tocotrienol rich fraction isolated from rice bran oil in experimentally induced hyperlipidemic rats. Food and Chemical Toxicology J. 43(5):747-753, May 2005. 15.  Iqbal, J, Minhajuddin, M. 2003. Suppression of 7,12-dimethylbenz[[alpha]]anthracene-induced carcinogenesis and hypercholesterolaemia in rats by tocotrienol-rich fraction isolated from rice bran oil. European J. of Cancer Prevention 12(6):447-453, Dec 2003.

Coenzyme Q10

Coenzyme Q10 (Co Q10) is a strong antioxidant and is an essential ingredient in the body's production of energy and in the normal metabolism of fat and energy. It participates in biochemical reactions in our bodies that provide energy. Scientists have long believed that Co Q10 produces beneficial effects to the heart,^1-5 brain,^1,6 kidneys,^1,7 and other tissues.^8-9

Co Q10 levels are reported to decrease with age and to be low in persons with some chronic diseases such as heart conditions, muscular dystrophies, Parkinson's disease, cancer, diabetes, and HIV/AIDS. Some prescription drugs may also lower Co Q10 levels. Depending on the cause of Co Q10 deficiency, supplementation or increased dietary intake of Co Q10 and the vitamins and minerals needed to produce Co Q10 may be effective.

A growing body of research suggests that using Co Q10 supplements alone or in combination with other drug therapies and nutritional supplements may help prevent or treat a variety of heart diseases including high blood pressure¹⁰. Researchers believe that the beneficial effect of CoQ10 in the prevention and treatment of heart disease is due to its ability to improve energy production in cells, inhibit blood clot formation, and its activity as a powerful antioxidant. A growing number of nutrition oriented doctors say that supplements of Co Q10 are absolutely essential for people with a variety of heart diseases, including cardiac failure.

These statements have not been evaluated by the U.S. Food and Drug Administration. These products are not intended to diagnose, cure or prevent any disease.

References
1.  Dhanasekaran M, Ren J. The emerging role of coenzyme Q-10 in aging, neurodegeneration, cardiovascular disease, cancer and diabetes mellitus. Curr Neurovasc Res 2005;2(5):447-59. 2.  Rosenfeldt FL, Pepe S, Linnane A, et al. Coenzyme Q10 protects the aging heart against stress: studies in rats, human tissues, and patients. Ann NY Acad Sci. 2002 Apr;959:355-9. 3.  Hodgson JM, Watts GF, Playford DA, Burke V, Croft KD. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr. 2002 Nov;56(11):1137-42. 4.  Greenberg S, Frishman WH. Co-enzyme Q10: a new drug for cardiovascular disease. J Clin Pharmacol. 1990 Jul;30(7):596-608. 5.  Thomas SR, Leichtweis SB, Pettersson K, et al. Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout mice. Arterioscler Thromb Vasc Biol. 2001 Apr;21(4):585-93.		6.  Matthews RT, Yang L, Browne S, Baik M, Beal MF. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci USA. 1998 Jul 21;95(15):8892-7. 7.  Gazdikova K, Gvozdjakova A, Kucharska J et al. [Effect of coenzyme Q10 in patients with kidney diseases]. Cas Lek Cesk. 2001 May 24;140(10):307-310. 8.  Feher J, Kovacs B, Kovacs I, et al. Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10. Ophthalmologica. 2005 May;219(3):154-66. 9.  Quiles JL, Farquharson AJ, Ramirez-Tortosa MC, et al. Coenzyme Q differentially modulates phospholipid hydroperoxide glutathione peroxidase gene expression and free radicals production in malignant and non-malignant prostate cells. Biofactors. 2003;18(1-4):265-70. 10.  Rosenfeldt FL, Haas SJ, Krum H, Hadj A, Ng K, Leong J-Y, Watts GF. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Human Hypertension 21: 297-306, 2007.

Curcumin

Alzheimer's disease (AD) is diagnosed (by autopsy) by the presences of what are called neurofibrillary tangles, senile plaques and loss of neurons. It is clear that oxidative stress and inflammation have an important role in AD. Curcumin is a compound with broad spectrum antioxidant, anti-inflamatory and anti-fibrilogenic activities. One recent study suggests that the natural product curcumin represents a "hopeful approach for delaying or preventing the progression of AD". Other studies have shown that curcumin prevents neural damage and reduces both oxidative stress and plaque accumulation. Curcumin prevents the formation of new deposits, clearing existing deposits, and reducing the size of remaining deposits. This data confirms that not only can curcumin suppress new plaques but also remove previous deposited ones. Data also shows that well known supplements, such as vitamin E and Ginkgo Biloba extract, have no effect on these plaques. Curcumin represents the "new frontier" of health supplements in disease prevention and treatment.

These statements have not been evaluated by the U.S. Food and Drug Administration. These products are not intended to diagnose, cure or prevent any disease.

References
•  Garcia-Alloza M, Borrelli LA, Rozkalne A. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J Neurochem 2007; 102(4): 1095–1104. •  Ono K, Naiki H, Yamada M. The development of preventives and therapeutics for Alzheimer's disease that inhibit the formation of beta-amyloid fibrils (fAbeta), as well as destabilize preformed fAbeta. Curr Pharm Des 2006; 12(33): 4357–4375. •  Yang F, Lim GP, Begum AN, et al. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vitro. J. Biol. Chem. 280:5892-5901.		•  Cole GM, Morihara T, Lim GP, et al. NSAID and antioxidant prevention of Alzheimer's disease: lessons from in vitro and animal models. Ann N.Y. Acad. Sci. 1035, 68-84. •  Kim DS, Kim JY, Han YS. Alzheimer's disease drug discovery from herbs: Neuroprotectivity from beta-amyloid (1-42) insult. J Altern Complement Med 2007; 13(3): 333–340. •  Mancuso C, Bates TE, Butterfield DA, et al. Natural antioxidants in Alzheimer's disease. Expert Opin Investig Drugs 2007; 16(12): 1921-1931.

Pomegranate

Pomegranate Extract is a powerful antioxidant containing polyphenols, tannins and anthocyanins. Recent scientific studies suggest that pomegranate may have beneficial effects on cardiovascular disease including atherosclerosis^1-2. These studies showed that carotid artery thickness decreased and cardiac blood flow improved with use of pomegranate. Preliminary evidence also suggests that pomegranate may help reduce levels of cholesterol and systolic blood pressure³.

In addition, pomegranate may help support healthy prostate function^4-7 and may have antibacterial effects against dental plaque⁸.

These statements have not been evaluated by the U.S. Food and Drug Administration. These products are not intended to diagnose, cure or prevent any disease.

References
1.  Aviram M et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr. 2004 Jun;23(3):423-33. 2.  Kaplan M, Hayek T, Raz A, Coleman R, Dornfeld L, Vaya J, Aviram M. Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J Nutr. 2001 Aug;131(8):2082-9. 3.  Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001 Sep;158(1):195–8. 4.  Pomegranates for the prostate and the heart: seeds of hope. Harv Mens Health Watch. 2007 Apr; 11(9):4-5.		5.  Seeram NP, Aronson WJ, Zhang Y et al. Subsequently, it has recently been found that pomegranate and its ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland. J Agric Food Chem. 2007 Sep 19;55(19):7732-7. 6.  N.P. Seeram et al. / Journal of Nutritional Biochemistry 16 (2005) 360–367. 7.  Pantuck, A. et al., "Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer.", Clinical Cancer Research, Vol. 12, 4018-4026, July 1, 2006. 8.  Menezes SM, Cordeiro LN, Viana GS (2006). "Punica granatum (pomegranate) extract is active against dental plaque". Journal of herbal pharmacotherapy 6 (2): 79–92.

Vitamin B12

Recent studies suggest an association between low Vitamin B12 levels and elevated homocysteine levels, which leads to cognitive impairment (dementia)^1-5. Elevated homocysteine concentrations contribute to cognitive impairment by causing atrophy (shrinking) of the brain^1-2. Studies suggest that supplementation of Vitamin B12 can both prevent this type of incident dementia and may even help reverse it^1-2. One recent study showed that both low concentrations of Folate (Vitamin B9) and Vitamin B12 were associated with twice the risk of developing Alzheimer's disease⁶.

These statements have not been evaluated by the U.S. Food and Drug Administration. These products are not intended to diagnose, cure or prevent any disease.

References
1.  Vogiatzoglou A, Refsum H, Johston S, et al. Vitamin B12 status and rate of brain volume loss in community-dwelling elderly. Neurology. 2008 Sep 9;71(11):826-32. 2.  Kim JM, Stewart R, Kim SW Changes in folate, vitamin B12 and homocystine associated with incident dementia. J Neurol. Neurosurg. Psychiatry 2008;79;864-868. 3.  Smith DA. Homocysteine, B vitamins, and cognitive deficit in the elderly. Am J Clin Nutr 2002;75:785–6.		4.  Tucker KL, Qiao N, Scott T, et al. High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study. Am J Clin Nutr. 2005 Sep;82(3):627-35. 5.  Duthie SJ, Whalley LJ, Collins AR, et al. Homocysteine, B vitamin status, and cognitive function in the elderly. Am J Clin Nutr 2002;75:908-913. 6.  Wang HX, Wahlin A, Basun H, et al. Vitamin B12 and folate in relation to the development of Alzheimer's disease. Neurolgy 2001;56:1188-94.

Whey Protein

Whey, a protein complex derived from milk, is being touted as a functional food with a number of health benefits. The biological components of whey, including lactoferrin, beta-lactoglobulin, alpha-lactalbumin, glycomacropeptide, and immunoglobulins, demonstrate a range of immune-enhancing properties. In addition, whey has the ability to act as an antioxidant, antihypertensive, antitumor, hypolipidemic, antiviral, antibacterial, and chelating agent. The primary mechanism by which whey is thought to exert its effects is by intracellular conversion of the amino acid cysteine to glutathione, a potent intracellular antioxidant. A number of clinical trials have successfully been performed using whey in the treatment of cancer, HIV, hepatitis B, cardiovascular disease, osteoporosis, and as an antimicrobial agent. Whey protein has also exhibited benefit in the arena of exercise performance and enhancement¹.

These statements have not been evaluated by the U.S. Food and Drug Administration. These products are not intended to diagnose, cure or prevent any disease.

References
1.  Marshall K. Therapeutic applications of whey protein. Altern Med Rev. 2004 Jun;9(2):136-56.